Outcomes of surgical treatment for carcinoid heart disease: A systematic review and meta-analysis

AbstractBackground Carcinoid heart disease (CaHD) develops from vasoactive substances released by neuroendocrine tumors, which can cause significant patient morbidity and mortality without surgical intervention. We performed a systematic review meta-analysis to elucidate granular perioperative details long-term outcomes in these patients. Methods Electronic search of Ovid, Scopus, Cumulative Index Nursing Allied Health Literature, Cochrane Controlled Trials Register was examine treatment carcinoid disease. Nine articles comprising 416 patients were selected. Study-level data extracted pooled for meta-analysis. Results Mean age 63 years (95% confidence interval, 57–70) with 53% 46–61) being male. In addition, 75% 54–96) tumors originated the small bowel or colon 98% 93–100) had liver metastases. Right failure present 48% 14–81). Moderate severe regurgitation 97% 95–99) tricuspid 72% 58–83) pulmonary valves. 99% 98–100) 59% 38–79) valves replaced. Bioprosthetic used 80% 68–93) positions. hospital duration stay 16 days 7–25). Thirty-day 9% 6–12). follow-up 25 months 11–39). Median survival 3 2.5–3.5). Conclusion For >18 age, be reasonable safety profile. However, overall appears have ongoing effects primary